Total serum cholesterol level in patients with major depressive disorder: Simple yet undermined

Human brain cholesterol acts as structural components of cellular membrane, synapse and dendrite formation.Researchers have found a possible association between low serum cholesterol levels and mood disorders though the literature from India in this regard is limited. To estimate serum levels of total cholesterol in patients with major depressive disorder. 75 patients of MDD were compared with equal number of age and sex matched controls. 5 ml of fasting sample of blood was obtained in a plain vacutainer to analyse total cholesterol level by Cholesterol oxidase-peroxidase method. Statistical analysis: The obtained results were tabulated and analyzed by multiple logistic regression analysis, independent t-test, Chi-square test and area under the curve. The mean level of cholesterol in cases (158.85±61.22 mg/dL) which was significantly lower compared to the controls (182.71±40.98 mg/dL) with P <0.01. The symptoms of MDD negatively correlated with lower serum cholesterol level with odds ratio of 0.99. There was statistically significant lower level of cholesterol in the MDD group below 140 mg/dL compared to the control group with P <0.001. As the measurement of total serum cholesterol is simple and cost effective, it can be used as an important biochemical marker for MDD.

Management of Single Rooted Mandibular First Molar A Rare Entity –A CBCT Analysis

The case report here tries to describe the rare variation of root canal morphology in a mandibular first molar, which is rare in occurrence in literature. This case report presents a relatively rare case of mandibular first molar with single root and a single root canal in a 24-year-old female patient.. Cone-beam computed tomography (CBCT) was employed to confirm the extension of the unusual anatomy. Ambiguity in the canal morphology of the first molar is quite common. Knowledge of variations in internal anatomy of teeth is important for success in endodontic treatment. Root canal morphology is limitless in its variability and clinicians must be aware that anatomic variations constitute a formidable challenge to endodontic success. Hence, clinicians have to take utmost care when these cases with single canal and single root come in our practice.